Authentic HIV-1 integrase inhibitors

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منابع مشابه

Progress in HIV-1 integrase inhibitors: A review of their chemical structure diversity

HIV-1 integrase (IN) enzyme, one of the three main enzymes of HIV-1, catalyzed the insertion of the viral DNA into the genome of host cells. Because of the lack of its homologue in human cells and its essential role in HIV-1 replication, IN inhibition represents an attractive therapeutic target for HIV-1 treatment. Since identification of IN as a promising therapeutic target, a major progress h...

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Progress in HIV-1 integrase inhibitors: A review of their chemical structure diversity

HIV-1 integrase (IN) enzyme, one of the three main enzymes of HIV-1, catalyzed the insertion of the viral DNA into the genome of host cells. Because of the lack of its homologue in human cells and its essential role in HIV-1 replication, IN inhibition represents an attractive therapeutic target for HIV-1 treatment. Since identification of IN as a promising therapeutic target, a major progress h...

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Identification of Authentic Inhibitors of HIV-1 Integration

Current strategies for the treatment of human immunodeficiency virus (HIV) infection are based on cocktails of drugs that target the viral entry step and the enzymes reverse transcriptase or protease. At present, the clinical benefit of this combination therapy for HIV-infected patients is considerable, although it is not clear how long this effect will last taking into account the emergence of...

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Title: Synthesis and Computational Studies on Hiv-1 Integrase Inhibitors

HIV-1 integrase (IN) is essential for viral replication and offers a promising target for the development of anti-retroviral drugs. Two decades of extensive research has lead to the recent approval of raltegravir as the first IN inhibitor. Advancement of drug candidate elvitegravir, which is currently in Phase III clinical trial, has furthermore accelerated efforts against this potential target...

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Peptide inhibitors of the HIV-1 integrase protein

Prof. Assaf Friedler was born in Haifa, Israel, in 1971. He did his undergraduate studies in chemistry at the Hebrew University of Jerusalem, and Ph.D studies in chemistry at the Hebrew University of Jerusalem under the supervision of Prof. Chaim Gilon, in peptide chemistry and medicinal chemistry. After receiving his PhD degree, in 2000, Prof. Friedler moved to Cambridge, UK, to do his post-do...

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ژورنال

عنوان ژورنال: Future Medicinal Chemistry

سال: 2010

ISSN: 1756-8919,1756-8927

DOI: 10.4155/fmc.10.199